Cytoskeletal Remodeling
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cytoskeletal |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include VIM (vimentin, mesenchymal cytoskeleton), TUBA1A (tubulin), TAGLN2 (transgelin, actin-binding), SEPTIN11 (septin cytoskeleton), ANXA1 (annexin, membrane/cytoskeletal), AHNAK (scaffold/cytoskeletal), FHL1 (LIM domain, cytoskeletal/actin), DPYSL3 (cytoskeletal dynamics), ATP2B1 (calcium pump). PBXIP1 is a transcriptional regulator. TSPAN2 is a tetraspanin (membrane organization). IDS (iduronate 2-sulfatase, lysosomal) is a peripheral member. The module is strongly cytoskeletal in character, dominated by actin/tubulin/intermediate filament genes. This likely reflects a cytoskeletal remodeling program active in a subset of HPCs undergoing morphological changes or early differentiation. Neighbor modules (M45 stemness, M47 vascular/quiescence) suggest this may represent the cytoskeletal complement of differentiating/migrating progenitors.
Genes
AHNAK, ANXA1, ATP2B1, DPYSL3, FHL1, IDS, MBOAT7, MTURN, PBXIP1, SEPTIN11, TAGLN2, TSPAN2, TUBA1A, VIM
Most correlated modules
- Cytokine Feedback Signaling · correlation 0.67
- HSC Stem Identity · correlation 0.46
- Glucocorticoid Response · correlation 0.41
- Erythroid Maturation Signaling · correlation 0.39
- T-cell Progenitor · correlation 0.38
- Interferon Stimulated · correlation 0.35
- HSC Quiescence Program · correlation 0.33
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.