NAF1 — Nuclear assembly factor 1 ribonucleoprotein
NAF1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NAF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Plasma cell secretory B cell maturation | AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, IDI1 +9 more | View in SCUBA |
| CD4⁺ T cells | RNA processing RNA processing | AARSD1, ABHD14A, AMD1, CALM2, CDKN2AIP, CHMP1B, FRAT1, HNRNPAB +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Processing Stress RNA processing & translation | DDX3X, ETV3, HSPA5, IVNS1ABP, KDM2A, RALGAPA1, SFPQ, SLC2A3 +3 more |
About the gene
| Chromosome | 4: 163110073-163166890 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | Ribosome biogenesis, rRNA processing |
Function
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.