RNA Processing Stress
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Top hubs SFPQ and DDX3X are multifunctional RNA-binding proteins involved in RNA processing and stress granule biology. KDM2A is a histone demethylase involved in chromatin regulation. TSC22D2 is a transcription factor. HSPA5 (GRP78/BiP) is a canonical ER stress chaperone. SLC2A3 is a glucose transporter upregulated under hypoxia/stress. IVNS1ABP is an RNA-binding protein. NAF1 is involved in telomerase/snoRNA biogenesis. ETV3 is a transcriptional repressor. The module combines RNA processing, ER stress, and chromatin regulation, with SFPQ/DDX3X RNA processing as dominant theme.
Genes
DDX3X, ETV3, HSPA5, IVNS1ABP, KDM2A, NAF1, RALGAPA1, SFPQ, SLC2A3, TSC22D2, TSPYL1, WHAMM
Most correlated modules
- NF-κB Negative Feedback · correlation 0.92
- Stress Granule Response · correlation 0.91
- AP-1/MEF2 Activation · correlation 0.89
- NF-κB Activation · correlation 0.89
- Stress-Induced Growth Arrest · correlation 0.85
- T cell Activation · correlation 0.85
- Integrated Stress Response · correlation 0.85
- mRNA Decay Program · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.