BCAS2 — BCAS2 pre-mRNA processing factor
BCAS2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCAS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Plasma cell secretory B cell maturation | AARSD1, ATP1B3, CHMP1B, DNAJB9, ELL2, ETV3, IDI1, MEPCE +9 more | View in SCUBA |
| CD4⁺ T cells | Immediate early activation TCR/AP1/NFKb pathway | ALG13, AREG, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2, PABPC1 +18 more | View in SCUBA |
| Gamma-delta T cells | ER Proteotoxic Stress Stress | ARL4A, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB, HSPA5 +13 more | |
| Innate lymphoid cells | NR4A Activation Response activation | ALG13, ARL4A, CASP3, CHMP1B, CREM, DDX24, DLL1, DNAJB9 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Negative Feedback Immune regulation | ARL4A, CSRNP1, CXCR4, ENSG00000285976, IDS, ITPRIP, NFKBIA, NFKBIB +7 more |
About the gene
| Synonyms | DAM1, Snt309, SPF27 |
|---|---|
| Chromosome | 1: 114567557-114581629 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | mRNA processing, mRNA splicing |
Function
Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.