Plasma cell secretory
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
Module mixes ER/secretory stress and NFkB-linked plasma cell differentiation genes: DNAJB9 (ER chaperone, XBP1 target), SELENOK (ER), ELL2 (plasma cell secretory program), NFKB2, ETV3, TIPARP. ELL2 and DNAJB9 are key drivers of antibody-secreting cell differentiation/ER expansion. Several lipid synthesis genes (IDI1, SC5D-like via sterol pathway) and NFKB2 indicate an activation-to-plasma-cell secretory program. delta_inflammation_CD significant.
Genes
AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, IDI1, MEPCE, NAF1, NFKB2, PRMT9, RNF139, SELENOK, TIPARP, TTC3, ZBTB10, ZNF891
Most correlated modules
- Immediate early response · correlation 0.93
- Hypoxia/metabolic stress · correlation 0.92
- Notch signaling · correlation 0.86
- B cell quiescence · correlation 0.83
- Integrated Stress Response · correlation 0.80
- NF-kB signaling · correlation 0.78
- Early Response Stress · correlation 0.75
- AP-1 Immediate Early · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.