NFATC2IP — Nuclear factor of activated T cells 2 interacting protein
NFATC2IP belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NFATC2IP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Nucleocytoplasmic Transport RNA processing & translation | KHDRBS1, KPNB1, MAT2A, RBMX, SNX5, SSR3, TRA2B | View in SCUBA |
| Gamma-delta T cells | Chromatin Architecture DNA/chromatin regulation | CBFB, CCDC137, CTCF, DCAF15, GMCL1, HNRNPUL2, HP1BP3, KDM4A +9 more | |
| Macrophages | Transcriptional Elongation Housekeeping | AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EIF5 +19 more | View in SCUBA |
About the gene
| Synonyms | ESC2, FLJ14639, NIP45, RAD60 |
|---|---|
| Chromosome | 16: 28950807-28967092 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT- driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.