KHDRBS1 — KH RNA binding domain containing, signal transduction associated 1
KHDRBS1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KHDRBS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Nucleocytoplasmic Transport RNA processing & translation | KPNB1, MAT2A, NFATC2IP, RBMX, SNX5, SSR3, TRA2B | View in SCUBA |
| Endothelial | mRNA Splicing RNA processing & translation | DIAPH1, EIF4A3, FUBP1, GLRX5, HNRNPA2B1, HNRNPA3, HNRNPD, MAGOH +8 more | View in SCUBA |
| Gamma-delta T cells | RNA Splicing Processing RNA processing & translation | ABCF2, ACTR1B, ARF3, C1orf35, CDK11B, DCAF8, DDX39B, EIF4EBP2 +16 more | |
| Goblet cells | Chromatin RNA Regulation chromatin regulation & transcription | ANP32A, CBX1, HDAC2, HNRNPA0, HNRNPM, NONO, RBMX, RCN2 +1 more | View in SCUBA |
| Innate lymphoid cells | Interferon-Stimulated Genes Inflammation | ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GNB2, GRINA +17 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
About the gene
| Synonyms | FLJ34027, p62, Sam68 |
|---|---|
| Chromosome | 1: 32013868-32060850 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Cell cycle, mRNA processing, Transcription, Transcription regulation |
Function
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA- 3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway- dependent manner. In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.