Nucleocytoplasmic Transport
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes: KHDRBS1 (Sam68, RNA binding, signal transduction), SNX5 (sorting nexin, endosomal trafficking), KPNB1 (importin-beta, nuclear import), SSR3 (signal sequence receptor, ER translocon), MAT2A (methionine adenosyltransferase, one-carbon metabolism), TRA2B (splicing regulator), NFATC2IP (NFAT coregulator), RBMX (RNA binding). Strong coherence. This is a smaller mixed module combining nuclear import (KPNB1), splicing (TRA2B, RBMX, KHDRBS1), ER translocation (SSR3), and metabolic (MAT2A) functions. KHDRBS1/Sam68 links splicing to signal transduction. In the batch context, the splicing/RNA processing theme continues, but the nuclear transport and ER components make this a more general nucleocytoplasmic trafficking module.
Genes
KHDRBS1, KPNB1, MAT2A, NFATC2IP, RBMX, SNX5, SSR3, TRA2B
Most correlated modules
- Proteostasis Translation · correlation 0.93
- RNA Processing Mixed · correlation 0.93
- Nuclear RNA Splicing · correlation 0.92
- Cellular Housekeeping · correlation 0.92
- OxPhos & Proteasome · correlation 0.91
- Replication Licensing · correlation 0.88
- S-phase Chromatin Replication · correlation 0.88
- Epigenetic Chromatin Maintenance · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.