NOC2L — NOC2 like nucleolar associated transcriptional repressor
NOC2L belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOC2L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA damage response DNA/chromatin regulation | ATP2B1, CENPC, DEAF1, FBXO34, HAX1, HECTD1, KMT5C, MRPL50 +7 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | CISD3, CNIH4, DDX52, DPH3, EXOSC6, FABP5, GTF2E2, IKBKE +20 more | View in SCUBA |
About the gene
| Synonyms | DKFZP564C186, NET15, NET7, NIR, PPP1R112 |
|---|---|
| Chromosome | 1: 944203-959309 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.