C1R — Complement C1r
C1R belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C1R's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Complement Innate Immune Inflammation | C1S, CD47, CNDP2, COL5A2, CTSS, GRINA, GSDMD, LGALS9 +9 more | View in SCUBA |
| Fibroblasts | Complement-secreting Fibroblast Immune interaction | ADI1, ARL6IP5, C2, CYB5A, FCGRT, FTH1, FTL, GPX4 +9 more | View in SCUBA |
| Glial cells | MHC-I Antigen Presentation Inflammation | B2M, BTN3A2, C1S, CST3, HLA-A, HLA-B, HLA-C, IFI27 +4 more | View in SCUBA |
| Smooth muscle cells | Non-muscle Actomyosin Cytoskeletal | CAST, CD63, CLIC1, DYNLL1, FILIP1L, LDHA, LIMS1, MYH9 +4 more | View in SCUBA |
About the gene
| Chromosome | 12: 7080214-7092540 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins |
Function
Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces.
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.