SCUBA

EWSR1 — EWS RNA binding protein 1

EWSR1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EWSR1's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsVesicle Trafficking
Protein processing & ER		AP2M1, ARF1, CDC37, GHITM, GNB2, LMAN2, PPP2CA, RAB11B +1 moreView in SCUBA
EndothelialStress RNA Processing
RNA processing & translation		ARF4, CACYBP, ELOC, ENY2, GNA14, HNRNPDL, HNRNPF, MAP3K13 +5 moreView in SCUBA
Gamma-delta T cellsmRNA Splicing
RNA processing & translation		ARHGDIA, DDX27, DDX59, EIF2AK1, FBXL5, GNL1, GTF2F1, HNRNPM +14 more
Innate lymphoid cellsILC Identity Program
Differentiation		AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 moreView in SCUBA
MacrophagesPre-mRNA Splicing
Housekeeping		BCLAF1, CSNK1A1, DDX3X, DDX5, FUS, HNRNPH1, HNRNPH3, HNRNPU +11 moreView in SCUBA

About the gene

SynonymsEWS
Chromosome22: 29268009-29300525
Predicted locationIntracellular
Essential geneYes
Protein classCancer-related genes, Disease related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionCalmodulin-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation

Function

Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.