MTPN — Myotrophin
MTPN belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTPN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | ER/vesicle trafficking Protein processing & ER | ATP6V0B, CD99, DIAPH1, HCST, M6PR, MTDH, REEP5, SCPEP1 +1 more | View in SCUBA |
| Fibroblasts | ER Protein Folding Housekeeping | AHCYL1, CANX, CSNK1A1, HNRNPK, HSP90B1, JAK1, KDELR1, KTN1 +10 more | View in SCUBA |
| Innate lymphoid cells | Splicing & Transcription RNA processing & translation | ACTR2, BDP1, CDC5L, CYLD, DHX36, FXR1, GPATCH2, PHF20L1 +12 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
| Pericytes | mRNA Stability Regulation Housekeeping | ACTR2, EIF4G2, HNRNPK, MTDH, QKI, SERBP1, SET | View in SCUBA |
About the gene
| Synonyms | GCDP, MYOTROPHIN, V-1 |
|---|---|
| Chromosome | 7: 135926760-135977359 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.