PHYH — Phytanoyl-CoA 2-hydroxylase
PHYH belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHYH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TRIM28-ZNF Repression DNA/chromatin regulation | B4GALT4, EEA1, FSCN1, HSPA2, ISG20L2, MAP3K13, MLF1, MORN3 +7 more | View in SCUBA |
| Enterocytes | Enterocyte lipid metabolism Lipid metabolism | CYP4F2, DHDH, GPX4, MS4A10, OCIAD2, PCK1, PLIN2, SAT2 +3 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1 +20 more |
About the gene
| Synonyms | PAHX, PHYH1, RD |
|---|---|
| Chromosome | 10: 13277796-13302412 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
Function
Catalyzes the 2-hydroxylation of not only racemic phytanoyl- CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl- and 4-methyl- branched acyl-CoAs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.