PITHD1 — PITH domain containing 1
PITHD1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PITHD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Heat Shock Response Stress | AHSA1, ANKRD37, DEDD2, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Activation Immune regulation | BCL3, FURIN, GTF3C1, IRAK1, IRS2, ISCA1, PRELID3B, RABGGTB +3 more |
About the gene
| Synonyms | C1orf128, HT014, TXNL1CL |
|---|---|
| Chromosome | 1: 23778418-23788232 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Promotes megakaryocyte differentiation by up-regulating RUNX1 expression. Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.