NF-κB Activation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
BCL3 is an IκB family member and NF-κB coactivator critical for T cell survival and proliferation. IRAK1 is a key kinase in TLR/IL-1R signaling upstream of NF-κB. IRS2 links PI3K/Akt signaling to cell survival. FURIN is a proprotein convertase that processes cytokines and receptors. UBE2D3 is a ubiquitin-conjugating enzyme involved in proteasomal degradation linked to NF-κB. RNF139 is an E3 ubiquitin ligase. ISCA1 is involved in iron-sulfur cluster assembly. The module reflects post-activation NF-κB/ubiquitin-proteasome signaling in MAIT cells.
Genes
BCL3, FURIN, GTF3C1, IRAK1, IRS2, ISCA1, PITHD1, PRELID3B, RABGGTB, RNF139, SNRPB, UBE2D3
Most correlated modules
- NF-κB RNA Regulation · correlation 0.88
- RNA Splicing m6A · correlation 0.85
- Rho GTPase Migration · correlation 0.85
- ER Stress UPR · correlation 0.84
- NF-κB Survival Signaling · correlation 0.83
- Metabolic Homeostasis · correlation 0.82
- cAMP Immune Regulation · correlation 0.80
- RUNX3 Tissue Identity · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.