DNAJB4 — DnaJ heat shock protein family (Hsp40) member B4

DNAJB4 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DNAJB4's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB6, EIF5 +13 more	View in SCUBA
CD4⁺ T cells	Heat Shock Response Stress	ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB1, HSP90AA1, HSP90AB1 +12 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	DNAJA4, DNAJB1, HSPA1A, HSPA1B, HSPA6, HSPB1, PLIN2, RGS2 +3 more	View in SCUBA
Fibroblasts	Cytokine Inflammatory Response Inflammatory	CXCL2, GFPT2, HES4, MAP3K8, MMP19, RASL11A, RGCC, RND3 +4 more	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, HSP90AA1 +13 more
Innate lymphoid cells	Heat Shock Response Stress	AHSA1, ANKRD37, DEDD2, DNAJB1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B +9 more	View in SCUBA
Lymphatic endothelial	Heat Shock Response Stress	BAG3, DNAJB1, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPB1, HSPE1 +3 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DUSP1 +39 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, GPR174 +13 more
Smooth muscle cells	BAG3-HSPB8 proteostasis Stress	BAG3, C6orf62, CREBRF, EOGT, GOLGB1, HSPB8, IFRD1, PPP2R5E +5 more	View in SCUBA

About the gene

Synonyms	HLJ1
Chromosome	1: 77979175-78017964
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Chaperone
Biological process	Stress response

Function

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.