ISCA1 — Iron-sulfur cluster assembly 1
ISCA1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ISCA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1 +19 more | View in SCUBA |
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more | |
| Mucosal-associated invariant T cell | NF-κB Activation Immune regulation | BCL3, FURIN, GTF3C1, IRAK1, IRS2, PITHD1, PRELID3B, RABGGTB +3 more | |
| Natural Killer cells | Circadian NF-κB Crosstalk Inflammation | DUSP8, IRF2BP2, MAP3K8, MED10, PER1, RELB, RHOH, SLC7A5 | View in SCUBA |
About the gene
| Synonyms | HBLD2, hIscA, ISA1, MGC4276 |
|---|---|
| Chromosome | 9: 86264546-86283102 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.