Heat Shock Response
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 18 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 18 genes have a known function matching the annotation |
Why this annotation
The module is dominated by heat shock proteins: HSPA1A, HSPA1B, HSPA8, HSPH1, HSPE1, HSPD1, HSP90AA1, HSP90AB1, DNAJB1, DNAJB4. TCP1 is a chaperonin. AHSA1 is an HSP90 co-chaperone. ZFAND2A is stress-inducible. MRPL18 is a mitoribosomal protein. Strong coherence with core memberships for most HSPs. This is a canonical proteotoxic/heat shock stress response module, co-expressed with the immediate-early module M72 as expected during cellular stress.
Genes
AHSA1, ANKRD37, DEDD2, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPD1, HSPE1, HSPH1, MRPL18, NOP56, PITHD1, TCP1, ZFAND2A
Most correlated modules
- Transcriptional Activation · correlation 0.90
- ILC3 Transcriptional Identity · correlation 0.89
- Immediate Early Response · correlation 0.86
- NK Cytokine Signaling · correlation 0.85
- Cytokine-driven Activation · correlation 0.84
- Dissociation Stress Response · correlation 0.84
- Integrated Stress Response · correlation 0.83
- NF-κB Inflammatory Activation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.