RABGGTB — Rab geranylgeranyltransferase subunit beta
RABGGTB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RABGGTB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Activation Immune regulation | BCL3, FURIN, GTF3C1, IRAK1, IRS2, ISCA1, PITHD1, PRELID3B +3 more |
About the gene
| Chromosome | 1: 75786197-75795086 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Prenyltransferase, Transferase |
Function
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.