PLA1A — Phospholipase A1 member A
PLA1A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLA1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Leukocyte Recruitment Signaling Inflammation | BIRC3, CELSR1, CSF2RB, HAPLN3, HSD3B7, IL34, IL7R, LTF +6 more | View in SCUBA |
| Lymphatic endothelial | Genotoxic Innate Inflammation Inflammation | CSF2, CSF3, E2F7, GBP2, NBN, RIPK2, SELENOM, SQOR +1 more | View in SCUBA |
About the gene
| Synonyms | ps-PLA1 |
|---|---|
| Chromosome | 3: 119597875-119629811 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1- acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity). Hydrolyzes lyso-PS but not PS
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.