SQOR — Sulfide quinone oxidoreductase
SQOR belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SQOR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Complement Innate Immune Inflammation | C1R, C1S, CD47, CNDP2, COL5A2, CTSS, GRINA, GSDMD +9 more | View in SCUBA |
| Lymphatic endothelial | Genotoxic Innate Inflammation Inflammation | CSF2, CSF3, E2F7, GBP2, NBN, PLA1A, RIPK2, SELENOM +1 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 more | View in SCUBA |
About the gene
| Synonyms | CGI-44, SQR, SQRDL |
|---|---|
| Chromosome | 15: 45631148-45691281 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.