PLEKHH2 — Pleckstrin homology, MyTH4 and FERM domain containing H2
PLEKHH2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLEKHH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CYGB+ Quiescent Fibroblast Housekeeping | CCND1, CYGB, FARP1, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1 +5 more | View in SCUBA |
| Pericytes | Pericyte Identity Differentiation Developmental | ADAMTS5, ARHGAP15, EPB41L2, GUCY1A1, INPP4B, LGI4, LMOD1, MAP1LC3A +11 more | View in SCUBA |
About the gene
| Synonyms | KIAA2028, PLEKHH1L |
|---|---|
| Chromosome | 2: 43637260-43767987 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.