GUCY1A1 — Guanylate cyclase 1 soluble subunit alpha 1
GUCY1A1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GUCY1A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | ABI3BP, ADRA2C, ANXA3, CGNL1, CLIC3, ELN, FBLN2, FGF18 +5 more | View in SCUBA |
| Fibroblasts | Complement-producing Fibroblast Inflammatory | ANK2, C3, CLSTN3, CYP7B1, DAAM1, DHRS3, GUCY1B1, LPAR1 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Megakaryocyte IFN-primed Inflammatory | COL24A1, ELK3, GBP4, HLA-E, IFI16, IQGAP2, MAML2, MYO5C +2 more | |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, EPB41, FBXO34, FGD6, ITGA6, MDFIC, NAV1 +13 more | View in SCUBA |
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLIC2 +22 more | View in SCUBA |
| Pericytes | Pericyte Identity Differentiation Developmental | ADAMTS5, ARHGAP15, EPB41L2, INPP4B, LGI4, LMOD1, MAP1LC3A, NFASC +11 more | View in SCUBA |
| Smooth muscle cells | NO-cGMP Signaling Contractility | AC005884.1, AC068888.1, AL355974.2, DEPP1, GUCY1B1, HIST1H4C, HOTAIRM1, REX1BD +2 more | View in SCUBA |
About the gene
| Synonyms | GC-SA3, GUC1A3, GUCY1A3 |
|---|---|
| Chromosome | 4: 155666726-155737059 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | cGMP biosynthesis |
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.