FARP1 — FERM, ARH/RhoGEF and pleckstrin domain protein 1
FARP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FARP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia Stress Response Stress | ABCA5, ALDH2, BAALC, CIRBP, EGLN3, EPB41, FTL, LRP5 +7 more | View in SCUBA |
| Fibroblasts | CYGB+ Quiescent Fibroblast Housekeeping | CCND1, CYGB, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1, PDK4 +5 more | View in SCUBA |
| Pericytes | Basement Membrane Assembly ECM production | F2R, ITGB1, JAK1, LAMA4, LAMC1, LIMS1, NID1, PELO +1 more | View in SCUBA |
About the gene
| Synonyms | CDEP, GLCC1, MGC87400, PLEKHC2, PPP1R75 |
|---|---|
| Chromosome | 13: 98142562-98455176 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein, Guanine-nucleotide releasing factor |
Function
Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.