LAMB1 — Laminin subunit beta 1
LAMB1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAMB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LGMN +11 more | View in SCUBA |
| Enterocytes | Serotonergic receptor signaling Secretion | HTR4, KCNQ3, LIMA1, NECTIN3, NFIB, TBC1D32 | View in SCUBA |
| Fibroblasts | Basement Membrane ECM ECM production | BSG, COL6A1, COL6A2, COMT, ECE1, ECM1, FNDC3B, LAMC1 +2 more | View in SCUBA |
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CASP4, CHSY1, FNDC3B, GMFG, ITPRIPL2, MARCKSL1, NECTIN2, OLFML2A +5 more | View in SCUBA |
| Smooth muscle cells | Collagen-Laminin Deposition ECM remodeling | COL5A1, COL5A2, COL6A3, LAMA4, NEGR1, PARVA, PCDH7, RAB32 +4 more | View in SCUBA |
About the gene
| Synonyms | CLM |
|---|---|
| Chromosome | 7: 107923799-108003213 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.