GJA1 — Gap junction protein alpha 1
GJA1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GJA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, DYSF, GRAMD1A, HDAC1, IGF2R, LAMB1, LGMN +11 more | View in SCUBA |
| Fibroblasts | Wnt-BMP Fibroblast Developmental | ABCC4, BMP7, EMID1, ETS1, GNG2, LEF1, MFGE8, PAPLN +5 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Vascular Stability endothelial development | GLT8D2, HIC1, HSD17B12, IGFBP4, KCTD12, MAF, ROBO4, S1PR1 +6 more | View in SCUBA |
| Smooth muscle cells | Synthetic Matrix Phenotype ECM remodeling | APOE, CFD, GAS6, MAP1LC3A, MXRA5, PHF14, PLAU, POSTN +1 more | View in SCUBA |
About the gene
| Synonyms | CX43, GJAL, ODD, ODDD, ODOD, SDTY3 |
|---|---|
| Chromosome | 6: 121435595-121449727 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
Function
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.