RAMP2 — Receptor activity modifying protein 2
RAMP2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAMP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ABR, AIF1L, ASS1, CCDC88C, CPNE8, EPHA4, IFITM2, MOB2 +5 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity endothelial development | ATP6AP2, BEX3, CD151, FDPS, GNG11, LMO2, MGST3, NAA38 +2 more | View in SCUBA |
About the gene
| Chromosome | 17: 42758447-42763041 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Transport |
Function
Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene- related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.