RHOF — Ras homolog family member F, filopodia associated
RHOF belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHOF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CCR5 effector migration migration & adhesion | ARHGEF12, BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12 +10 more | View in SCUBA |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I +18 more | View in SCUBA |
About the gene
| Synonyms | ARHF, FLJ20247, RIF |
|---|---|
| Chromosome | 12: 121777754-121803403 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.