ATP6V0B — ATPase H+ transporting V0 subunit b
ATP6V0B belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V0B's module in each cell type
About the gene
| Synonyms | ATP6F, HATPL, VMA16 |
|---|---|
| Chromosome | 1: 43974487-43978295 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted membrane proteins |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.