DR1 — Down-regulator of transcription 1
DR1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ARL3, ATP2B4, ATXN1, GDE1, GNA15, GRAMD1B, GTDC1, ITGA4 +8 more | View in SCUBA |
| Gamma-delta T cells | T Cell Phosphatase Signaling TCR Signaling | AMZ2, ASTE1, DNAJB11, EFCAB2, IFIT3, PSMD14, PTPN7, SAR1A +4 more | |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, EIF3I, HPRT1 +18 more | View in SCUBA |
About the gene
| Synonyms | NC2-BETA, NC2B, NCB2 |
|---|---|
| Chromosome | 1: 93345907-93369493 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.