RNF149 — Ring finger protein 149
RNF149 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF149's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Transcriptional regulation DNA/chromatin regulation | CCNH, CWC25, DYNLL2, EIF2A, GOLGB1, IVNS1ABP, JMJD1C, KRR1 +8 more | View in SCUBA |
| Macrophages | Sphingolipid Membrane Homeostasis Lipid metabolism | ACER3, AGPAT3, ARHGEF11, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8 +12 more | View in SCUBA |
About the gene
| Synonyms | FLJ90504 |
|---|---|
| Chromosome | 2: 101271219-101308701 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.