SAE1 — SUMO1 activating enzyme subunit 1
SAE1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SAE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ACTL6A, LMNB1, RRM2, SMC2, SSRP1, TFDP1, TYMS, UBE2T +2 more | View in SCUBA |
| CD4⁺ T cells | Cellular biosynthesis Housekeeping | CCDC32, CTSB, HDGF, MEA1, MESD, MFSD6, MRPS11, MTHFD2 +9 more | View in SCUBA |
| CD8⁺ T cells | Replication Licensing Cell cycle | ACYP1, DDB2, DSN1, GMNN, HIRIP3, ITGB3BP, LSM3, MAGOHB +8 more | View in SCUBA |
About the gene
| Synonyms | AOS1, FLJ3091, Sua1 |
|---|---|
| Chromosome | 19: 47113274-47210636 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | Ubl conjugation pathway |
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.