SMC2 — Structural maintenance of chromosomes 2
SMC2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ACTL6A, LMNB1, RRM2, SAE1, SSRP1, TFDP1, TYMS, UBE2T +2 more | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, BIRC5, CENPN, CENPW, CKS1B, DTYMK, GGH, PRR11 +3 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN +13 more | |
| Goblet cells | S/G2 Preparation Cell cycle | DTYMK, EXOSC8, HMGN2, LMNB1, LSM3, LSM5, MIS18A, MIS18BP1 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | S-phase Progression Cell cycle | ATAD2, ATAD5, BRCA2, DNMT1, FANCI, LMNB1, RRM1, TMPO +1 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
| Natural Killer cells | G2/M Transition Cell cycle | ANP32B, CARHSP1, NSD2, PHF19, STMN1, TMPO, TUBA1B, TUBB | View in SCUBA |
About the gene
| Synonyms | CAP-E, hCAP-E, SMC2L1 |
|---|---|
| Chromosome | 9: 104094260-104141419 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, DNA condensation, Mitosis |
Function
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.