Replication Licensing
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 17 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 17 genes have a known function matching the annotation |
Why this annotation
GMNN (geminin, replication licensing inhibitor), RFC3 (replication factor C), DSN1 (kinetochore), TFDP1 (DP-1, E2F heterodimerization partner), SSRP1 (FACT complex, chromatin remodeling during replication), RBBP7 (chromatin assembly), DDB2 (DNA damage recognition, also E2F target), YEATS4 (chromatin reader), SAE1 (SUMO E1, active in S-phase), NUDT1 (sanitizes nucleotide pool), ITGB3BP (centromere-associated), HIRIP3 (HIRIP3, histone), MAGOHB (mRNA splicing). The module integrates replication licensing, chromatin assembly, and E2F-driven S-phase transcription. TFDP1/GMNN/DDB2 anchor it as an E2F/replication licensing program. Neighbor context: consistent with the broader S-phase cluster in this batch.
Genes
ACYP1, DDB2, DSN1, GMNN, HIRIP3, ITGB3BP, LSM3, MAGOHB, NUDT1, RBBP7, RFC3, RTN3, SAE1, SSRP1, TFDP1, YEATS4, ZDHHC12
Most correlated modules
- S-phase Progression · correlation 0.98
- Cellular Housekeeping · correlation 0.96
- Mitotic Spindle · correlation 0.96
- Mitochondrial Metabolism · correlation 0.95
- General Housekeeping · correlation 0.95
- G2/M Checkpoint · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.93
- Mitotic Spindle Assembly · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.