UBE2T — Ubiquitin conjugating enzyme E2 T
UBE2T belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2T's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ACTL6A, LMNB1, RRM2, SAE1, SMC2, SSRP1, TFDP1, TYMS +2 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Assembly Cell cycle | FBXO5, LRR1, MELK, MTFR2, NCAPG2, RAD51AP1, SHCBP1, SKA1 +3 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN +14 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | ASF1B, BUB1, CDCA8, CENPE, CENPF, CKS1B, EZH2, MAD2L1 +12 more | |
| Goblet cells | S/G2 Preparation Cell cycle | DTYMK, EXOSC8, HMGN2, LMNB1, LSM3, LSM5, MIS18A, MIS18BP1 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Checkpoint Cell cycle | CENPF, CENPW, CKS1B, GGH, HMGB2, MAD2L1, PTTG1, ZWINT | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | FANCT, HSPC150 |
|---|---|
| Chromosome | 1: 202331544-202341984 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.