TYMS — Thymidylate synthetase
TYMS belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TYMS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ACTL6A, LMNB1, RRM2, SAE1, SMC2, SSRP1, TFDP1, UBE2T +2 more | View in SCUBA |
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPM, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF +5 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, ATAD5, BRCA1, BRCA2, CENPH, CENPK, CENPU, DHFR +11 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN +13 more | |
| Goblet cells | S-phase DNA Replication Cell cycle | ASF1B, BRCA1, CDC6, CENPU, DHFR, FEN1, MYBL2, PCLAF +1 more | View in SCUBA |
| Hematopoietic progenitor cells | DNA Replication S-phase Cell cycle | CDT1, CENPH, CENPK, CHEK1, E2F1, FEN1, GINS2, GMNN +4 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
| Natural Killer cells | S-phase Replication Cell cycle | CDT1, CENPM, CENPU, CLSPN, FANCI, PCLAF, RRM2 | View in SCUBA |
About the gene
| Synonyms | HsT422, TMS, TS, Tsase |
|---|---|
| Chromosome | 18: 657653-673578 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
| Biological process | Nucleotide biosynthesis |
Function
Catalyzes the reductive methylation of 2'-deoxyuridine 5'- monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1- carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.