LMNB1 — Lamin B1
LMNB1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LMNB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ACTL6A, RRM2, SAE1, SMC2, SSRP1, TFDP1, TYMS, UBE2T +2 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASF1B, CENPN, DDX39A, DTYMK, GGH, HMGB2, HMGN2, STMN1 +3 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN +14 more | View in SCUBA |
| Goblet cells | S/G2 Preparation Cell cycle | DTYMK, EXOSC8, HMGN2, LSM3, LSM5, MIS18A, MIS18BP1, SMC2 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | S-phase Progression Cell cycle | ATAD2, ATAD5, BRCA2, DNMT1, FANCI, RRM1, SMC2, TMPO +1 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Chromosome | 5: 126776623-126837020 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.