SAP30 — Sin3A associated protein 30
SAP30 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SAP30's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | PD-L1 checkpoint Immune regulation | ADAM12, CASS4, CCDC88B, CD274, GALNT10, HUWE1, INPP5D, KIF3B +13 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Repression DNA/chromatin regulation | CAPN12, CFAP210, CNOT10, EPS8L2, FKBP5, H1-10, HAGHL, IL6ST +8 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | BHLHE40, BRD4, CASK, CITED2, GLUL, GNAS, HECA, IGFBP7 +19 more | View in SCUBA |
| Monocytes | Glucocorticoid Response Tissue adaptation | FKBP5, FMN1, MIS18BP1, NUDT16, SMAP2, SPTLC2, SULT1A1, TSC22D3 +2 more | View in SCUBA |
About the gene
| Chromosome | 4: 173369969-173377532 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.