SEC63 — SEC63 homolog, protein translocation regulator
SEC63 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEC63's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2 +23 more | View in SCUBA |
| Neutrophils | Endocytic Vesicular Trafficking Vesicular traficking | CLINT1, DNAJC13, LNPK, PHACTR2, PRAM1, PRKAA1, PTPN22, VCL |
About the gene
| Synonyms | DNAJC23, ERdj2, PRO2507, SEC63L |
|---|---|
| Chromosome | 6: 107867756-107958208 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Chaperone |
| Biological process | Protein transport, Transport |
Function
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin- 1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.