SLC15A3 — Solute carrier family 15 member 3
SLC15A3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC15A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Type I Interferon Response Inflammation | ADAR, DDX60, DTX3L, IFIH1, LAP3, OAS2, ODF3B, PARP9 +3 more | View in SCUBA |
| Glial cells | Glial Neuroprotective Response Neroprotection | ANXA4, CYB5A, DPYSL3, DRAP1, FADS2, IGFBP4, MDK, NBDY +4 more | View in SCUBA |
| Macrophages | ER Protein Quality Control Lysosomal & pahgocytosis | ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GANAB +18 more | View in SCUBA |
| Neutrophils | NF-κB Activation Inflammatory | EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLEK +6 more |
About the gene
| Synonyms | hPTR3, PHT2 |
|---|---|
| Chromosome | 11: 60937060-60952653 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Immunity, Innate immunity, Peptide transport, Protein transport, Symport, Transport |
Function
Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.