Glial Neuroprotective Response

Gene co-expression module in Glial cells

View this module in SCUBA

Why this annotation

Hub genes: IGFBP4 (IGF-binding protein 4, modulates IGF signaling, expressed by enteric glia in neuroprotective/repair contexts), SLC15A3 (peptide/histidine transporter, lysosomal, innate immune response to bacterial peptides), CYB5A (cytochrome b5, ER lipid/drug metabolism), NBDY (negative regulator of P-body assembly, mRNA decay), PHPT1 (phosphohistidine phosphatase), NDUFB2 (Complex I subunit), FADS2 (fatty acid desaturase 2, PUFA synthesis), DPYSL3 (dihydropyrimidinase-like 3/CRMP4, neuronal/glial axon guidance, highly expressed in enteric glia), RASSF4 (Ras-association domain family, tumor suppressor/apoptosis), PXDN (peroxidasin, ECM crosslinking/oxidative), ANXA4 (annexin A4, membrane/calcium), MDK (midkine, neurotrophic/heparin-binding growth factor, neuroprotection/repair), DRAP1 (DR1-associated protein, transcriptional repressor). Strongly upregulated in both UC and CD inflammation. IGFBP4, MDK, and DPYSL3 are glial neuroprotective/repair factors. SLC15A3 links to innate immune sensing. FADS2 and CYB5A suggest lipid remodeling. This module represents an inflammation-induced glial repair/neuroprotection program with IGF and midkine signaling.

Genes

ANXA4, CYB5A, DPYSL3, DRAP1, FADS2, IGFBP4, MDK, NBDY, NDUFB2, PHPT1, PXDN, RASSF4, SLC15A3

Most correlated modules

• ER-Mitochondria Housekeeping · correlation 0.88
• Mitochondrial OxPhos Integrity · correlation 0.83
• ER Membrane Homeostasis · correlation 0.81
• Rho GTPase Signaling · correlation 0.81
• ENS Developmental TFs · correlation 0.78
• MHC-I Antigen Presentation · correlation 0.75
• Actin Remodeling Migration · correlation 0.74
• Basement Membrane Adhesion · correlation 0.74

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.