OAS2 — 2'-5'-oligoadenylate synthetase 2
OAS2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OAS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Interferon-stimulated Genes Inflammation | ADAR, GBP1, PARP14, PARP9, RNF213, SAMD9, SAMD9L, SP110 +3 more | View in SCUBA |
| Endothelial | Type I Interferon Response Inflammation | ADAR, DDX60, DTX3L, IFIH1, LAP3, ODF3B, PARP9, SLC15A3 +3 more | View in SCUBA |
| Gamma-delta T cells | Interferon Stimulated Genes Inflammation | AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN +14 more | |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1 +13 more | View in SCUBA |
| Monocytes | Type I Interferon Response Antiviral | EPSTI1, IFI44, IFI44L, IFI6, IRF7, MX1, OAS3, PARP12 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, HERC5 +18 more |
About the gene
| Chromosome | 12: 112978395-113011723 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Nucleotidyltransferase, RNA-binding, Transferase |
| Biological process | Antiviral defense, Immunity, Innate immunity |
Function
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.