Type I Interferon Response
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
This module is strongly upregulated in inflammation (both UC and CD) and downregulated in remission, a pattern consistent with interferon-stimulated gene (ISG) induction. Hub genes SP100, PARP9, ADAR, IFIH1 (MDA5), DTX3L, OAS2, OAS1, DDX60, ZNFX1, and SP110 are all well-established interferon-stimulated genes involved in innate antiviral defense. LAP3 (leucine aminopeptidase 3) and SLC15A3 are also ISGs. This is a tight, coherent type I/II interferon response module. Neighbor context: sits near M143 and M86 which are also interferon/MHC-related modules, forming a cluster of interferon-driven programs in inflamed endothelium.
Genes
ADAR, DDX60, DTX3L, IFIH1, LAP3, OAS2, ODF3B, PARP9, SLC15A3, SP100, SP110, ZNFX1
Most correlated modules
- IFN-gamma Antigen Processing · correlation 0.85
- Type I Interferon · correlation 0.82
- MHC Class I Presentation · correlation 0.75
- Vascular EC Identity · correlation 0.70
- IFN-gamma Response · correlation 0.65
- Endothelial Barrier Homeostasis · correlation 0.58
- Arterial EC Homeostasis · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.