BPI — Bactericidal permeability increasing protein
BPI belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BPI's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | BPI Antibacterial Response Antibacterial | ADGRG3, ANXA3, CMTM2, CST7, CYP4F3, LGALS12, MGAM, RGL4 +6 more | View in SCUBA |
| Neutrophils | Immature Neutrophil Granule Developmental | CCDC85B, CD24, CEACAM8, CPNE3, OLFM4, RETN, RGCC, SVIP |
About the gene
| Synonyms | BPIFD1 |
|---|---|
| Chromosome | 20: 38304150-38337505 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins, Transporters |
| Molecular function | Antibiotic, Antimicrobial |
| Biological process | Immunity, Innate immunity |
Function
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.