TNFAIP8L3 — TNF alpha induced protein 8 like 3
TNFAIP8L3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFAIP8L3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Subepithelial Fibroblast Identity Developmental | ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, EFEMP1, FAM107A +12 more | View in SCUBA |
| Smooth muscle cells | KLF6/ZNF24 regulators Activation | ACSL3, ARHGAP1, CTBP2, KLF6, PLEKHA4, SCAF11, ZNF24 | View in SCUBA |
About the gene
| Synonyms | FLJ41287 |
|---|---|
| Chromosome | 15: 51056598-51105276 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e. phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.