KLF6/ZNF24 regulators
Gene co-expression module in Smooth muscle cells
| Category | Activation |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Small, moderately coherent module whose hubs are transcriptional regulators (ZNF24, KLF6, CTBP2, SCAF11) plus lipid/membrane genes (ACSL3, PLEKHA4) and TNFAIP8L3 (PI transfer protein). KLF6 and ZNF24 are stress/injury-responsive TFs in smooth muscle and fibroblasts; the mixture with ACSL3 and weak memberships suggests a loosely defined transcription-factor activation state rather than a single pathway. Neighborhood (STAT3 module M15, TGF-beta/ID module M60) supports a general transcriptional activation interpretation.
Genes
ACSL3, ARHGAP1, CTBP2, KLF6, PLEKHA4, SCAF11, TNFAIP8L3, ZNF24
Most correlated modules
- STAT3 transcriptional program · correlation 0.71
- Chaperonin heat-shock · correlation 0.69
- Atrophy Proteolysis Program · correlation 0.67
- Cytoskeletal trafficking kinases · correlation 0.66
- Actin Cytoskeletal Scaffold · correlation 0.65
- BAG3-HSPB8 proteostasis · correlation 0.65
- Translation initiation/RNA-binding · correlation 0.61
- Lipid Kinase Signaling · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.