KLF6 — KLF transcription factor 6

KLF6 belongs to a gene co-expression module in 17 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KLF6's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Activation/Migration BCR/AP1/NFKb pathway	AHNAK, DUSP10, DUSP8, GGA1, GPR183, GPR65, IDS, LDLRAD4 +11 more	View in SCUBA
CD4⁺ T cells	Glucocorticoid Immunoregulation Immune regulation	AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, IRS2, JUND +11 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, EIF5, GADD45B, IER5, JUN +6 more	View in SCUBA
Endothelial	Inflammatory Angiogenesis Endothelial cell development	FAM241A, FAM43A, MYC, NFATC1, PHLDA1, PIM3, PLEKHO2, RALGDS +7 more	View in SCUBA
Enterocytes	EGFR wound response Epithelial development	CLDN4, DDX60L, ERRFI1, GPRC5A, SNX9, STOM	View in SCUBA
Fibroblasts	BMP-ID Stress Response Stress	BHLHE40, CCDC184, CFAP20, FOXC2, GADD45G, GDF15, GDNF, HAS1 +9 more	View in SCUBA
Gamma-delta T cells	ER Proteotoxic Stress Stress	ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more
Goblet cells	Stress Survival Response Stress	EPHA2, ERRFI1, EZR, LDLR, LMNA, MCL1, NEDD9, SQSTM1 +3 more	View in SCUBA
Hematopoietic progenitor cells	Glucocorticoid Response Inflammatory	ARL4C, CYTH1, EMP1, ETS1, FOS, LRRFIP1, PDE4B, PTPRC +4 more
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	NF-κB Negative Feedback Inflammation	BMP2, C2CD4B, ICAM1, IRF8, MAFF, NFIL3, NFKBIA, PRNP +4 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	AP-1 Inflammatory Activation Inflammatory	COQ7, DUSP1, FOS, IER2, JUN, JUNB, KCNE1, NAIP +2 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1 +7 more
Natural Killer cells	AP-1 Immediate Early activation	BTG1, CITED2, CXCR4, DUSP1, DUSP2, FOS, JUN, JUNB +1 more	View in SCUBA
Neutrophils	KLF2 Survival Response Stress	BEST1, FOSB, IDS, JMJD1C, KLF2, MYADM, RASSF5, YPEL5 +1 more
Smooth muscle cells	KLF6/ZNF24 regulators Activation	ACSL3, ARHGAP1, CTBP2, PLEKHA4, SCAF11, TNFAIP8L3, ZNF24	View in SCUBA

About the gene

Synonyms	BCD1, COPEB, CPBP, GBF, PAC1, ST12, Zf9
Chromosome	10: 3775996-3785281
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.