FAM107A — Family with sequence similarity 107 member A
FAM107A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAM107A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Quiescence Identity Endothelial cell development | ABCC4, ARHGAP5, C1orf115, ENPP4, GIT2, IFNAR2, LRRFIP1, MSI2 +8 more | View in SCUBA |
| Fibroblasts | Subepithelial Fibroblast Identity Developmental | ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, EFEMP1, FGF13 +12 more | View in SCUBA |
| Pericytes | Vascular Barrier Integrity Migration & adhesion | C1orf115, GIMAP1, GIMAP4, GIMAP7, ITGB4, JAM2, MYCT1, NRN1 +2 more | View in SCUBA |
About the gene
| Synonyms | DRR1, TU3A |
|---|---|
| Chromosome | 3: 58564117-58627610 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Cell cycle, Growth regulation, Stress response |
Function
Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.