DUSP10 — Dual specificity phosphatase 10
DUSP10 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DUSP10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activation/Migration BCR/AP1/NFKb pathway | AHNAK, DUSP8, GGA1, GPR183, GPR65, IDS, KLF6, LDLRAD4 +11 more | View in SCUBA |
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1, RBBP8 +6 more | View in SCUBA |
| Gamma-delta T cells | Stress Negative Feedback Immune regulation | ANKRD12, AZIN1, CCDC186, CDKN1A, CYLD, DENND4A, DNAJB6, ELL +7 more | |
| Monocytes | Inflammatory Stress Response Stress | ARL5B, ATF3, CCRL2, CD83, IL1B, NFE2L2, RASGEF1B, SGK1 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Effector Activation Inflammation | ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, EGR2 +10 more | |
| Natural Killer cells | NF-κB Activation Inflammation | ADGRE5, BCL3, BHLHE40, CSRNP1, NFKB1, NFKB2, NINJ1, OTULIN +3 more | View in SCUBA |
About the gene
| Synonyms | MKP-5, MKP5 |
|---|---|
| Chromosome | 1: 221701424-221742089 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.