TRAK1 — Trafficking kinesin protein 1
TRAK1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRAK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenic Activation Inflammation | ALPL, APOL4, ASAP2, CALM1, COMMD2, FAT4, PDGFB, PLS3 +4 more | View in SCUBA |
| Macrophages | Ubiquitin Proteasome Regulation Housekeeping | ARIH1, BTAF1, CLASP2, DENND4A, DYRK1A, FBXO11, FBXW7, GATAD2B +8 more | View in SCUBA |
About the gene
| Synonyms | KIAA1042, MILT1, OIP106 |
|---|---|
| Chromosome | 3: 42013802-42225890 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.